Laboratory features associated with severe COVID-19
| Abnormality | Possible threshold |
| Elevations in: | |
| >1000 ng/mL (normal range: <500 ng/mL) |
| >100 mg/L (normal range: <8.0 mg/L) |
| >245 units/L (normal range: 110 to 210 units/L) |
| >2× the upper limit of normal (normal range for troponin T high sensitivity: females 0 to 9 ng/L; males 0 to 14 ng/L) |
| >500 mcg/L (normal range: females 10 to 200 mcg/L; males 30 to 300 mcg/L) |
| >2× the upper limit of normal (normal range: 40 to 150 units/L) |
| Decrease in: | |
| <800/microL (normal range for age ≥21 years: 1800 to 7700/microL) |
Although these laboratory features are associated with severe disease in patients with COVID-19, they have not been clearly demonstrated to have prognostic value. We use the thresholds listed above to identify patients who may be at risk for severe disease; they are extrapolated from published cohort data and individualized to the reference values used at our laboratory. However, the specific thresholds are not well established and may not be applicable if laboratories use other reference values.
COVID-19: coronavirus disease 2019; CRP: C-reactive protein; LDH: lactate dehydrogenase; CPK: creatine phosphokinase.
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